Protein Key To Combating Lung Cancer Identified

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Medical researchers have found that inhibiting a protein called BMI1 could impair tumour growth in lung cancer.

Reducing the levels of BMI1 by genetic means, or by using a drug reducing expression of BMI1, led to inhibition of tumour formation, the findings showed.

The researchers believe that the findings of this study, published in the journal Science Translational Medicine, would contribute to the development of better therapies for cancer patients.

Lung cancer is one of the deadliest cancers in the world, accounting for 30 per cent of tumour-related deaths.

Like many solid tumours, lung cancer is very heterogeneous (consisting of cancer cells which behave and respond differently) and hence there is currently no single efficient drug which is able to treat all patients.

The study was led by Professor Daniel Tenen, Director of Cancer Science Institute of Singapore at National University of Singapore and his associate at Elena Levantini at Harvard Stem Cell Institute.